Premature Ventricular Complex–Induced Cardiomyopathy

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Association between cytokines and two circulating micro-RNAs and development of premature ventricular contractions-induced cardiomyopathy

Objective(s): Recent progress in understanding the pathogenesis of premature ventricular contraction (PVC)-induced cardiomyopathy (PIC) has suggested a key role for inflammation. The aim of this study was to evaluate the expression of messenger RNAs (mRNAs) and the protein production of interleukin-6 (IL-6), IL-10, tumor necrosis factor alpha (TNF-α) and interferon-γ (...

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Premature ventricular contraction-induced cardiomyopathy: a treatable condition.

Premature ventricular contractions (PVCs) are early depolarizations of the myocardium originating in the ventricle. They are often seen in association with structural heart disease and represent increased risk of sudden death,1 yet they are ubiquitous, even in the absence of identifiable heart disease.1,2 They may cause troubling and sometimes incapacitating symptoms such as palpitations, chest...

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Frequent Premature Ventricular Contractions and Cardiomyopathy, Chicken and Egg situation.

Premature ventricular contractions (PVCs) are usually regarded as benign in the absence of structural heart disease. However, frequent PVCs can lead to depressed LV function, called PVC-induced cardiomyopathy and can be reversible after suppression of PVCs. On the other hand, PVCs can be a part of underlying structural heart disease and may be linked to increased risk of sudden death. In this w...

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Premature ventricular complexes (PVCs) in the absence of known structural heart disease used to be considered a benign entity. Early studies supporting this conclusion were limited by small sample sizes and limited cardiac testing during follow-up. More recent work has revealed the long-term effects of frequent PVCs and their ability to cause or contribute to cardiomyopathy and heart failure sy...

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ژورنال

عنوان ژورنال: JACC: Clinical Electrophysiology

سال: 2019

ISSN: 2405-500X

DOI: 10.1016/j.jacep.2019.03.013